School of Medicine

Wayne State University School of Medicine

Faculty Profile

Carolyn Anne Harris, PhD
Title
Assistant Professor
Phone
(313) 745-5122

Childrens Hospital of Michigan
2nd Floor Carls Building
3901 Beaubien Blvd, Detroit MI 48201

Biography

The Harris laboratory studies hydrocephalus with a prudent focus on bioengineering strategies that could improve treatment. As an Assistant Professor of Neurosurgery with a joint appointment in biomedical engineering, Dr. Harris plays a critical role in quantifying the cellular response to brain injury. Dr. Harris received her B.S. from Purdue University in 2006 and her Ph.D. from the University of Utah in 2011, both in Biomedical Engineering. Dr. Harris is nationally and internationally recognized as an expert in hydrocephalus due to her comprehension of the pathophysiology of the disorder and her investigation into shunt obstruction and shunt infection utilizing unique model systems.

In addition to her academic activities, Dr. Harris is deeply committed to improving public education and cultivating communication and a sincere connection with patients. These interests are fostered from a multilevel perspective with specific attention to teaching undergraduate, graduate, and medical students, residents and fellows, and by reaching out to the community to interact with patients and their families. Questions are always welcomed.

Publications
  1. Harris C, Pearson K, Trett K, Zhu S, Chong P, Taskin N, Shain W: Fabrication of three-dimensional hydrogel scaffolds for modeling cortical tissue obstruction in hydrocephalus Experimental Neurology (in preparation)
  2. Harris C, Pearson K, Trett K, Zhu S, Chong P, Taskin N, Shain W : Retrograde Flushing Induced Shear Stress Reduces Astrocyte Attachment and Growth on Ventricular Catheters. Biomaterials (in preparation)
  3. Harris C, Trett K, Chong P, Zhu S, Taskin N, Pearson K, Shain W : Electrophoresis as a novel method for increased antibody penetration through thick tissue samples. Nature Methods (in preparation)
  4. Megjhani M, Mukherjee A, Rey N, Merouane A, Lu Y, Trett K, Chong P, Harris C, Shain W, Roysam B. IEEE Biomaterials (submitted April 2014)
  5. Harris C, McAllister JP II: What We Should Know About the Cellular and Tissue Response Causing Catheter Obstruction in the Treatment of Hydrocephalus (Review). Neurosurgery. 70(6): 1589-601, discussion 1601-2
  6. Eskandari R, Harris CA, McAllister JP II: Reactive astrocytosis in feline neonatal hydrocephalus: acute, chronic, and shunt-induced changes. Child's Nervous System. 27(12): 2067-76, 2011
  7. Harris C, Resau J, Hudson E, West R, Moon C, Black AD, McAllister JP II: Reduction of Protein Adsorption and Macrophage and Astrocyte Adhesion on Ventricular Catheters by Polyethylene Glycol and N-Aceytl-L-Cysteine. Journal of Biomedical Materials Research Part A. 98(3):425-33, 2011
  8. Harris C, McAllister JP II: Does drainage hole size influence adhesion on ventricular catheters? Child's Nervous System. 27(8):1221-32, 2011
  9. Harris C, Resau J, Hudson E, West R, Moon C, Black AD, McAllister JP II: Effects of surface wettability, flow, and protein concentration on macrophage and astrocyte adhesion in an in vitro model of central nervous system catheter obstruction. Journal of Biomedical Materials Research Part A. 97(4): 443-440, 2011
  10. Harris C, Resau J, Hudson E, West R, Moon C, McAllister JP II: Mechanical contributions to astrocyte adhesion using a novel in vitro model of catheter obstruction. Experimental Neurology. 222(2):204-210, 2010
  11. Black C, Resau J, West R, Grever W, McAllister JP II: Are We Implanting Shunt Catheters that Facilitate Shunt Failure? Fluids and Barriers of the CNS. 6 (Suppl 1):S42. (published abstract)
  12. Wang A, Liang X, McAllister JP, Li J, Black C, Finlayson P, Cao T, Tang C, Salley S, Auner G, Ng KYS. 2007. Stability of and inflammatory response to silicon coated with a fluoroalkyl self-assembled monolayer in the central nervous system. Journal of Biomedical Materials Research Part A 81(2): 363-372, 2007
  13. Wang A, McAllister JP II, Finlayson PG, Li J, Brabant KE, Tang H, Black CE, Cao T, Liang X, Salley SO, Auner GW, Ng KYS: Short- and long-term neural biocompatibility of heparin coated sapphire implants. Materials Science & Engineering C-Biomimetic and Supramolecular Systems. 27(2):237-243, 2007
  14. Wang A, Cao T, Tang H, Liang X, Black C, Salley SO, McAllister JP II, Auner GW, Ng KYS. 2006. Immobilization of polysaccharides on a fluorinated silicon surface. Colloids and Surfaces B Biointerfaces 47(1): 57-63, 2006
     
Links of Interest
Fellowships

2011-2014
Postdoctoral Fellow
Center for Integrative Brain Research
Seattle Childrens Research Institute
Seattle, Washington

2011
Postdoctoral Fellow, Neurosurgery
University of Utah
Salt Lake City, Utah

Graduate Education
2011
PhD, Bioengineering
University of Utah
Salt Lake City, Utah