Glioma Bioenergetics Research: Saroj Mathupala, PhD
Saroj P. Mathupala, PhD
Assistant Professor, Neuro-Oncology
Department of Neurosurgery
Wayne State University School of Medicine
Assistant Professor, Neuro-Oncology
Karmanos Cancer Institute
Phone: (313) 576-8352
Fax: (313) 576-8306
Education and Training
- BSc. (Hon.), Chemistry, University of Colombo, Sri Lanka
- PhD, Biochemistry and Molecular Biology, Michigan State University, E. Lansing, Michigan (Advisor, Prof. J. Greg Zeikus)
- Postdoctoral Fellow, Tumor Bioenergetics & Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland (Advisor, Prof. Peter L. Pedersen)
Malignant brain tumors are usually detected during late stages of their progression - and they are heterogeneous – carrying many genetic mutations that enable them to withstand most clinical interventions including chemotherapy and radiotherapy. However, these highly aggressive tumors harbor several deviant biochemical features that are absent in the surrounding healthy brain tissue. Foremost is the tumor’s propensity to engross excessive amounts of glucose from blood and metabolize it into lactic acid. In general, the more aggressive the tumor, the greater is its capacity for producing lactic acid.
B: Day 14 - a cannula is placed in the growing brain tumor and connected to a miniature osmotic pump primed with a test drug that inhibits lactic acid efflux. The pump is placed under the skin between shoulder blades and will work for just 28 days and pump drug into the tumor at 0.25 microliters per hour.
C: Day 56 - complete necrosis of the tumor – pump has shut down 14 days before, but tumor has not regrown. The empty cavity is filled with CSF (cerebrospinal fluid).
D: Day 120 – No regrowth of the tumor. Animal survives.
E: The growth of an untreated tumor 20 days after implanting tumor.
Current and future research will involve both proteomic and metabolomic approaches using 3D brain tumor spheroid cultures and orthotopic nude rat human brain tumor models to identify additional metabolic targets in brain tumors, and to further enhance the efficacy of our previous findings.
Former and Current Students
The projects are undertaken by both neurosurgery residents (as partial fulfillment of their Ph.D. requirements), and by research associates, medical students/graduate students and undergraduates.
|Richard Rhiew, MD||PhD||2002-2004|
|Chaim Colen, MD||PhD||2003-2005|
|Todd Francis, MD||PhD||2006-2010|
|Praveen Sateesh||Yr. III Medical Student||2002 Summer|
|Chantel Njiwaji||Yr. III Medical Student||2004 Summer|
|Andrew Lozen||Yr. IV Medical Student||2008 Summer|
|Charles Kraftchak||Yr. IV Medical Student||2008 Summer|
|Amy Buth||Yr. I MD/PhD Student||2008-2011|
|Ajal Dave||Yr. IV Medical Student|
|Research Associates & Graduate Students:|
|Pingyang Yu, MD||Research Associate||2002-2006|
|Akannsha Singh, MBBS||Graduate Student||2005-2007|
|Philip Benson, MS||Research Assistant||2008-2009|
|Michael Monterey,BS||Research Assistant||2009-2012|
|Noah Heilbrun||Kalamazoo College||2000 & 2002 Summers|
|Scott Gallagher||University of Michigan||2001 Summer|
|Khari Wilson||Grambling State University||2003 Summer|
|Sharon Lu||Yale University||2003 & 2004 Summers|
|Brandon Koch||Rollins College||2005-2009 Summers|
|Mouli Mandalaparty||Wayne State University||2009 Summer|
|James Caruso||University of Michigan||2009-2013|
|Bhavika Chepuri||Wayne State University||2009-2012|
|Elsa Varughese||Wayne State University||2009-2012|
|Jane Harness||University of Michigan||2011 Summer|
|Alexandra Chrumka||Stanford University||2012 Summer|
|Bridget Reno||Wanye State University||2012-|
|Dr. Andrew E. Sloan, Associate Professor, Department of Neurological Surgery, Case Western Reserve University Medical School, Cleveland, Ohio.|
|Dr. Sandeep Mittal, Assistant Professor, Department of Neurosurgery, and Chief, Neuro-oncology, Karmanos Cancer Institute, Wayne State University School of Medicine.|
|Dr. Nicholas Szerlip, Assistant Professor, Department of Neurosurgery, Wayne State University School of Medicine, Karmanos Cancer Institute.|
|American Cancer Society (IRG)||2000-2002|
|LEARN Foundation, Michigan||2002-2006|
|National Cancer Institute/National Institutes of Health (R01)||2006-2013|
|Fund for Medical Research and Education (FMRE), Wayne State University School of Medicine||2004-2006
|Marvin E. Klein, MD, Charitable Trust||2005-2014|